Gillian Booth MD (Active Staff, Clinician Investigator [60% protected research time]); Associate Scientist at the Institute for Clinical Evaluative Sciences (ICES)). Major research interests: Diabetes outcomes and models to improve care delivery, with a focus on reducing barriers for vulnerable groups, and the epidemiology of diabetes in high-risk urban populations. Dr. Booth is a co-editor of an upcoming ICES atlas on Diabetes in Ontario, and a member of the expert panel for the development of the 2003 Canadian Diabetes Association Guidelines.
Telephone: 416-867-3719
Fax: 416-867-3724
E-mail: gillian.booth@utoronto.ca
Philip W. Connelly PhD (Staff Scientist) Director of University of Toronto Core Lipid Laboratory.
My current research interests involve 1) the role of peroxynitrite and paraoxonase-1 in the oxidative modification of lipoproteins; and 2) the study of C-reactive protein and homocysteine in the Sandy Lake Oji-Cree, an aboriginal population with a high prevalence of diabetes. Project number 1 is funded by the Heart and Stroke foundation and has been successfully renewed for 2002-2005. Project number 2 is funded by the Canadian Diabetes Association and is a collaboration with Dr. Stewart B. Harris, Dr. Bernie Zinman and Dr. Robert A. Hegele, and has been submitted for renewal. In addition to these primary research activities, I have active research collaborative projects with Dr. Dominic Ng (transgenic mice and HDL metabolism in models of atherosclerosis), Dr David Jenkins (lipoprotein changes with diet), Dr. Tom Wolever (prediabetic state and diet), and Dr. Ian Crandall (oxidized lipoproteins and the receptor CD36). The laboratory continues to maintain standardization of lipid measurements with the NHLBI-CDC Lipid Standardization Program.
Telephone: 416-864-6023
Fax: 416-864-5870
E-mail: p.connelly@utoronto.ca
Christine M. Derzko MD (Active Staff, Primary appointment in the Department of Obstetrics & Gynecology with a cross-appointment to the Division of Endocrinology) Major clinical and research interests in reproductive endocrinology & infertilty particularly in the areas of menopause, osteoporosis, premature ovarian failure, sexual dysfunction. Also appointed to the Ontario Cancer Institute/Princess Margaret Hospital Actively involved in undergraduate and resident teaching and in CME presentations and program development. Administrative responsibilities: Member of several committees involved in development of consensus statements notably Society of Obstetricians and Gynecologists of Canada major document on Menopause & Osteoporosis (1998 & 2001) (Senior Editor 2001) and the Expert Panel of the SOGC and Heart & Stoke Canada in preparation of their joint statement on HRT and Cardiovascular Disease. (2002)
Telephone: 416-867-7447
Fax: 416-867-3693
E-mail: derzkoc@smh.toronto.ca
Jeannette Goguen MD (Active Staff, Clinician Educator) Major administrative activities: Chair of the Postgraduate Medical Education Committee of St. Michael’s Hospital, Co-Chair of Diabetes Comprehensive Care Program Education Committee at SMH; Research interests: How do medical trainees and faculty conceptualize “scientific research”? What do they believe are the underlying assumptions and biases in scientific research? How are different forms of scientific research valued? Currently completing Masters of Education at OISE
Telephone: 416-867-3714
Fax: 416-867-3724
E-mail: goguenj@smh.toronto.on.ca
Amir K. Hanna MD (Active Staff, Clinician Teacher) Administrative responsibilities: Director, Diabetes Clinics, SMH; Vice-chair Scientific, Clinical & Scientific Section, Canadian Diabetes Association; Member, Steering committee, Clinical Practice Guidelines, Canadian Diabetes Association; Editor-in-Chief, Diabetes Dialogue, Canadian Diabetes Association; Co-chair, Organizing Committee, CDA/CSEM Annual Conference & Scientific Meeting, Vancouver, BC. October 2-5, 2002 Co-investigator: NIH funded ACCORD study; NAVIGATOR study, CIHR funded Assessment of consequences of maternal severe hypoglycemia during pregnancy in women with type 1 diabetes on the offspring’s neuropsychological functioning
Telephone: 416-867-3721
Fax: 416-867-3724
E-mail: hannaa@smh.toronto.on.ca
Sophie Jamal MD PhD (Active Staff, Clinician Scientist (80% protected research time)) (commencing at SMH July 1, 2002) has held a CIHR Phase 1 Clinician Scientist Award since 1998. Her research interests are the prevention and treatment of osteoporosis in men and other populations at risk and the relationship between osteoporosis, nitric oxide and cardiovascular disease.
Telephone: 416-867-3701
Fax: 416-867-3696
E-mail: sophie.jamal@utoronto.ca
David JA Jenkins MD PhD (Clinician Scientist) Dr Jenkins’ primary appointment is in the University of Toronto Dept of Nutritional Sciences but is geographically located at SMH. He is the Director of the Clinical Nutrition and Risk Factor Modification Center at SMH. His research area is the use of diet in the prevention and treatment of hyperlipidemia and diabetes. He has over 200 original publications on these and related topics. His team was the first to define and explore the concept of the glycemic index of foods and demonstrate the breadth of metabolic effects of viscous soluble fiber. He currently holds a Canada Research Chair in Metabolism and Nutrition and has received National and International awards in recognition of his contribution to nutrition research.
Telephone: 416-867-7474
Fax: 416-867-7495
E-mail: david.jenkins@utoronto.ca
R.G. Josse, MD (Active Staff, Clinician Researcher [50% Patient Care and Teaching, 40% Research, 10% Administration]) Major administrative responsibilities: Director, Osteoporosis Centre; Immediate Past President, Canadian Society of Endocrinology and Metabolism. Primary Research Interests: In two areas of Endocrinology and Metabolism: a) calcium disorders and metabolic bone disease, b) diabetes, clinical nutrition. Grant funding is both peer and non-peer-reviewed. Heavily involved in CME at all levels (city-wide, nationally and internationally).
Telephone: 416-867-7455
Fax: 416-867-3696
E-mail: josser@smh.toronto.on.ca
LA Leiter MD (Active Staff, Clinical Researcher (50% Patient Care and Teaching, 40% Research, 10% Administration)). Major administrative responsibilities: Division Chief; Executive Committee SMH Dept of Medicine; Executive DCCP; Director, Lipid Clinic; Past Chair, Clinical & Scientific Section, Canadian Diabetes Association. Research interests: Steering Committees of a number of large Outcome Studies (EARTH, NAVIGATOR, SATURN) in diabetes and lipid areas, local PI of NIH funded ACCORD trial, clinical research into control of appetite and dietary and pharmacologic treatment of dyslipidemia, obesity and diabetes and its complications. Heavily involved in CME at regional, national and international levels.
Telephone: 416-867-7441
Fax: 416-867-3696
E-mail: leiter@smh.toronto.on.ca
Timothy Murray MD (Active Staff, Clinician Scientist) Clinical activities are almost exclusively limited to diseases of calcium and bone metabolism. Research activities: Dr. Leticia Rao and he have recently found that estrogen and raloxifene both stimulate bone nodule formation when added intermittently to the cultures, a novel finding emphasizing the bone forming effects of estrogenic drugs. They are using similar systems to study the effects of space flight on bone formation in an experiment scheduled to be launched in the Space Shuttle Flight STS-107 on July 11, 2002. Finally, they have recently demonstrated potent direct effects of antioxidants on osteoclastic bone resorption in vitro, the first demonstration of effects of antioxidants on bone turnover. As Director of the Toronto site of the Canadian Multicentre Osteoporosis Study (CaMos), a leading epidemiological study of osteoporosis carried out in nine centres across Canada, Dr. Murray has recently co-authored a number of publications resulting from this study. He is currently planning a national study of the endocrinology of male osteoporosis in the 2800 male CaMos subjects. He is active in clinical trials in collaboration with others in the Division, and has been the local PI on two studies of zoledronate in osteoporosis and Paget's Disease.
Telephone: 416-864-5291
Fax: 416-864-5434
E-mail: tim.murray@utoronto.ca
Dominic S. Ng MD PhD (Active Staff, Clinician Scientist (80% protected research time)) Main research activities utilize genetically modified mouse models to study the relationship between dyslipidemia, oxidation and vascular pathology pertaining to atherosclerosis and thrombosis with a particular focus on high density lipoprotein metabolism. Other research activities include participating in clinical trials on lipid lowering drugs. Clinical activities include a ½ day per week attending at the Lipid Clinic and ½ day week of a private general endocrine office practice. Administrative responsibilities: Member research committees for the Heart and Stroke Foundation of Canada, Banting and Best Diabetes Center at the University of Toronto: member of Postgraduate Education Committee for the Division of Endocrinology at the University of Toronto; Toronto Diabetes Association.
Telephone: 416-864-5197
Fax: 416-864-5870
E-mail: ngd@smh.toronto.on.ca
Leticia G. Rao, PhD (Staff Scientist, Academic appointment in the Department of Medicine, University of Toronto, 90% research). My research interests are as follows: 1. Studies on the role of stage of differentiation on hormonal action in human osteoblasts; 2. Clinical studies on the role of oxidative stress and antioxidant in osteoporosis; 3. Effect of microgravity due to space flight on bone formation; and 4. Studies on the mechanisms of action of PTH, estrogen and the selective estrogen modulator (SERM) raloxifene and its analog on bone formation
Telephone: 416-864-5838
Fax: 416-864-5434
E-mail: leticia.rao@utoronto.ca
Vladimir Vuksan, Ph.D. (Staff Scientist job description [70% protected research time]). Major administrative responsibilities: Associate Director, Clinical Nutrition & Risk Factor Modification Centre, SMH; Director, Clinical Trials, Clinical Nutrition & Risk Factor Modification Centre, SMH. Research Interests: Clinical and epidemiological investigations of diet and lifestyle in the treatment and prevention of diabetes and hypertension, with an emphasis on the study of alternative therapies. Alternative therapies studied currently include American and Korean ginseng, konjac-mannan soluble fibre, w-3 fatty acid-rich seeds and “portfolio” combinations of these. Epidemiological interventions focusing primarily on risk factor-clustering in ethnic populations in Canada.
Telephone: 416-867-7450
E-mail: v.vuksan@utoronto.ca
Qinghua Wang MD PhD (Staff Scientist) Research has been focused on islet function and, in particular, to identify the factors that determine B-cell mass under physiologic conditions or in response to insulin resistance. Also interested in the intra-pancreatic hormonal regulation and how this regulation contributing to glucose homeostasis and currently investigating the mechanism of hyperglycemia-induced suppression of glucagon secretion.
Tel. (416) 864-6060 Ext.6767
Fax (416) 864-6043
Thomas MS Wolever MD PhD (Clinician Scientist) Dr Wolever’s primary appointment is in the University of Toronto Dept of Nutritional Sciences but is geographically located at SMH. Research interests: Principal investigator of a CIHR-funded randomized, multi-centre trial investigating the effect of altering the amount or source of dietary carbohydrate for one year in the management of type 2 diabetes. Two other studies are also underway investigating the effects of cereal fibre on colonic short chain fatty acids, appetite, GLP-1, glucose and insulin profiles, blood lipids and body fat distribution in hyperinsulinemic subjects. Administrative responsibilities: Graduate Coordinator for the Department of Nutritional Sciences, Deputy Editor of the British Journal of Nutrition, Editorial Board of Diabetes Care, Personnel Awards Committee and the Expert Committee of the Revision of Clinical Practice Guidelines for the Canadian Diabetes Association. Clinical work consists of one morning per week at the Lipid Clinic.
Telephone: 416-978-5556
Fax: 416-978-5882
E-mail: thomas.wolever@utoronto.ca
Minna Woo, MD PhD (Active Staff, Clinician Scientist [80% protected research time]). Major research interests: Elucidating mechanisms of islet apoptosis in vivo and in vitro using genetic approach in mouse models. Understanding the role of caspases in the final destructive phase of apoptosis in type 1 DM and investigation of islet apoptosis related to type 2 DM.
Telephone: 416-946-2000 x 3971
Fax: 416-867-3696
E-mail: mwoo@oci.utoronto.ca
Robert Zeman MD (Active Staff, Clinician Teacher) Former Director of Nuclear Medicine
Department, Wellesley Site. He currently continues his clinical practice in endocrinology and internal medicine.
Telephone: 416-925-1224
Fax: 416-923-5234
E-mail: robert.zeman@sympatico.ca